ANCA associated pauci-immune retinal vasculitis
نویسندگان
چکیده
منابع مشابه
ANCA associated pauci-immune retinal vasculitis.
BACKGROUND Antinuclear cytoplasmic antibodies (ANCA) are useful diagnostic serological markers for the most common forms of necrotising vasculitis. ANCA associated vasculitides represent distinctive clinicopathological categories--for example, Wegener's granulomatosis, Churg-Strauss syndrome, microscopic polyangiitis, and idiopathic necrotising crescentic glomerulonephritis, collectively known ...
متن کاملPauci-Immune Crescentic Glomerulonephritis: An ANCA-Associated Vasculitis
Rapidly progressive glomerulonephritis (RPGN) is a syndrome signified by a precipitous loss of renal function, with features of glomerulonephritis including dysmorphic erythrocyturia and glomerular proteinuria. RPGN is associated with extensive crescent formation, and, thus, the clinical term RPGN is often used interchangeably with the pathologic term crescentic glomerulonephritis (CGN). From a...
متن کاملMechanisms of vasculitis: how pauci-immune is ANCA-associated renal vasculitis?
Both the innate and the acquired immune system are involved in the pathophysiology of renal vasculitis. However, anti-neutrophil cytoplasmic antibody (ANCA)-associated renal vasculitis is characterized by a 'pauci-immune' pattern of immunofluorescence during kidney biopsy, indicating the relative lack of immunoglobulin and complement deposition within the kidney. On the other hand, evidence is ...
متن کاملANCA-negative pauci-immune renal vasculitis: histology and outcome.
BACKGROUND Pauci-immune renal vasculitis with focal glomerular necrosis and crescent formation is usually associated with anti-neutrophil cytoplasmic antibodies (ANCAs). However, ANCA's are absent in up to 10% of cases, which constitutes a rarely studied variant of renal vasculitis. METHODS This retrospective multicentre cohort study analyzed the presenting features, renal histology and outco...
متن کاملAnti-LAMP-2 autoantibodies in ANCA-associated pauci-immune glomerulonephritis.
The association between anti–lysosome-associatedmembrane protein 2 (LAMP-2) autoantibodies and vasculitis is not new; it dates back to work by Kain et al.1 in 1995 that identified LAMP-2 as a target of antineutrophil cytoplasmic antibodies (ANCA) in 14 of 16 patients with a pauci-immune necrotizing crescentic glomerulonephritis. LAMP-2 makes an intriguing target for ANCA; it is a major constitu...
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ژورنال
عنوان ژورنال: British Journal of Ophthalmology
سال: 2005
ISSN: 0007-1161
DOI: 10.1136/bjo.2004.051177